Subject provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include: general mechanisms of disease (inflammation, infection, immune injury, host response to foreign materials, transplantation, genetic disorders and neoplasia); pathology of lipids, enzymes, and molecular transporters; pathology of major organ systems; and review of diagnostic tools from invasive surgical pathology to non-invasive techniques such as optical spectroscopy, functional imaging, and molecular markers of disease. The objectives of this subject are achieved by a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology.

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Develop skills as science communicators through projects and analysis of theoretical principles. Case studies explore the emergence of popular science communication over the past two centuries and consider the relationships among authors, audiences and media. Project topics are identified early in the term and students work with MIT Museum staff. Projects may include physical exhibits, practical demonstrations, or scripts for public programs.

The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.

Principles of Continuum Applied Mathematics covers fundamental concepts in continuous applied mathematics, including applications from traffic flow, fluids, elasticity, granular flows, etc. The class also covers continuum limit; conservation laws, quasi-equilibrium; kinematic waves; characteristics, simple waves, shocks; diffusion (linear and nonlinear); numerical solution of wave equations; finite differences, consistency, stability; discrete and fast Fourier transforms; spectral methods; transforms and series (Fourier, Laplace). Additional topics may include sonic booms, Mach cone, caustics, lattices, dispersion, and group velocity.

This course introduces the design of feedback control systems as applied to a variety of air and spacecraft systems. Topics include the properties and advantages of feedback systems, time-domain and frequency-domain performance measures, stability and degree of stability, the Root locus method, Nyquist criterion, frequency-domain design, and state space methods.

This course surveys a variety of reasoning, optimization and decision making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their application, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, and machine learning. Optimization paradigms include linear programming, integer programming, and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes.

"This course provides an introduction to the chemistry of biological, inorganic, and organic molecules.ĺĘTheĺĘemphasis isĺĘon basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis. In an effort to illuminate connections between chemistry and biology, a list of the biology-, medicine-, and MIT research-related examples used in 5.111 is provided in Biology-Related Examples. Acknowledgements Development and implementation of the biology-related materials in this course were funded through an HHMI Professors grant to Prof. Catherine L. Drennan."

Principles of Computer System Design: An Introduction is published in two parts. Part I, containing chapters 1-6, is a traditional printed textbook published by Morgan Kaufman, an imprint of Elsevier. Part II, containing chapters 7-11, is available here as an open educational resource. This textbook, an introduction to the principles and abstractions used in the design of computer systems, is an outgrowth of notes written for 6.033 Computer System Engineering over a period of 40-plus years. Individual chapters are also used in other EECS subjects. There is also a Web site for the current 6.033 class with a lecture schedule that includes daily Assignments and Labs, lecture notes, and lecture slides. The 6.033 class Web site also contains a thirteen-year archive of class Assignments and Labs, design projects, and quizzes. Technical Requirements: Special software is required to use some of the files in this resource: .key, .ppt, and .zip.

Deals with more advanced design theories and textual analysis. Emphasis on script analysis in general, as well as from a designer's perspective. Students also refine technical skills in rendering and presentation, historical research, and analysis. Class sessions include interaction with student/faculty directors and other staff designers. Goal is for students to approach text with a fresh vision and translate that vision into design for performance.

" The course serves as an introduction to the theory and practice behind many of today's communications systems. 6.450 forms the first of a two-course sequence on digital communication. The second class, 6.451 Principles of Digital Communication II, is offered in the spring. Topics covered include: digital communications at the block diagram level, data compression, Lempel-Ziv algorithm, scalar and vector quantization, sampling and aliasing, the Nyquist criterion, PAM and QAM modulation, signal constellations, finite-energy waveform spaces, detection, and modeling and system design for wireless communication."

This class introduces students to the interdisciplinary nature of 21st-century engineering projects with three threads of learning: a technical toolkit, a social science toolkit, and a methodology for problem-based learning. Students encounter the social, political, economic, and technological challenges of engineering practice by participating in real engineering projects with faculty and industry; this semester's major project focuses on the engineering and economics of solar cells. Student teams will create prototypes and mixed media reports with exercises in project planning, analysis, design, optimization, demonstration, reporting and team building.

Covers current understanding of and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Specific topics include the genetics of simple and complex traits; Karyotypic analysis and positional cloning; genetic diagnosis; the roles of oncogenes and tumor suppressors in tumor initiation, progression and treatment; the interaction between genetics and environment; animal models of human disease; cancer; and conventional and gene therapy treatment strategies.

This course covers the principles of main group (s and p block) element chemistry with an emphasis on synthesis, structure, bonding, and reaction mechanisms.

"This course is designed to introduce classic macroeconomic issues such as growth, inflation, unemployment, interest rates, exchange rates, technological progress, and budget deficits. The course will provide a unified framework to address these issues and to study the impact of different policies, such as monetary and fiscal policies, on the aggregate behavior of individuals. These analytical tools will be used to understand the recent experience of the United States and other countries and to address how current policy initiatives affect their macroeconomic performance."

Principles of Microeconomics is an introductory undergraduate course that teaches the fundamentals of microeconomics. This course introduces microeconomic concepts and analysis, supply and demand analysis, theories of the firm and individual behavior, competition and monopoly, and welfare economics. Students will also be introduced to the use of microeconomic applications to address problems in current economic policy throughout the semester.

This course presents principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form, intact and damage stability, hull structure strength calculations and ship resistance. It introduces computer-aided naval ship design and analysis tools. Projects include analysis of ship lines drawings, calculation of ship hydrostatic characteristics, analysis of intact and damaged stability, ship model testing, and hull structure strength calculations.

This course introduces theoretical and practical principles of design of oceanographic sensor systems. Topics include: transducer characteristics for acoustic, current, temperature, pressure, electric, magnetic, gravity, salinity, velocity, heat flow, and optical devices; limitations on these devices imposed by ocean environments; signal conditioning and recording; noise, sensitivity, and sampling limitations; and standards. Lectures by experts cover the principles of state-of-the-art systems being used in physical oceanography, geophysics, submersibles, acoustics. For lab work, day cruises in local waters allow students to prepare, deploy and analyze observations from standard oceanographic instruments.

Studies the principles of deterministic optimal control. Variational calculus and Pontryagin's maximum principle. Applications of the theory, including optimal feedback control, time-optimal control, and others. Dynamic programming and numerical search algorithms introduced briefly.

An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and substance abuse. Selected agents and classes of agents examined in detail.