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ATP: The Fuel of Life
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The goal of this lesson is to introduce students who are interested in human biology and biochemistry to the subtleties of energy metabolism (typically not presented in standard biology and biochemistry textbooks) through the lens of ATP as the primary energy currency of the cell. Avoiding the details of the major pathways of energy production (such as glycolysis, the citric acid cycle, and oxidative phosphorylation), this lesson is focused exclusively on ATP, which is truly the fuel of life. Starting with the discovery and history of ATP, this lesson will walk the students through 8 segments (outlined below) interspersed by 7 in-class challenge questions and activities, to the final step of ATP production by the ATP synthase, an amazing molecular machine. A basic understanding of the components and subcellular organization (e.g. organelles, membranes, etc.) and chemical foundation (e.g. biomolecules, chemical equilibrium, biochemical energetics, etc.) of a eukaryotic cell is a desired prerequisite, but it is not a must. Through interactive in-class activities, this lesson is designed to spark the students’ interest in biochemistry and human biology as a whole, but could serve as an introductory lesson to teaching advanced concepts of metabolism and bioenergetics in high school depending on the local science curriculum. No supplies or materials are needed.

Subject:
Life Science
Biology
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Christian Schubert
Date Added:
04/07/2020
ATP: The Fuel of Life
Conditional Remix & Share Permitted
CC BY-NC-SA
Rating

The goal of this lesson is to introduce students who are interested in human biology and biochemistry to the subtleties of energy metabolism (typically not presented in standard biology and biochemistry textbooks) through the lens of ATP as the primary energy currency of the cell. Avoiding the details of the major pathways of energy production (such as glycolysis, the citric acid cycle, and oxidative phosphorylation), this lesson is focused exclusively on ATP, which is truly the fuel of life. Starting with the discovery and history of ATP, this lesson will walk the students through 8 segments (outlined below) interspersed by 7 in-class challenge questions and activities, to the final step of ATP production by the ATP synthase, an amazing molecular machine. A basic understanding of the components and subcellular organization (e.g. organelles, membranes, etc.) and chemical foundation (e.g. biomolecules, chemical equilibrium, biochemical energetics, etc.) of a eukaryotic cell is a desired prerequisite, but it is not a must. Through interactive in-class activities, this lesson is designed to spark the students’ interest in biochemistry and human biology as a whole, but could serve as an introductory lesson to teaching advanced concepts of metabolism and bioenergetics in high school depending on the local science curriculum. No supplies or materials are needed.

Subject:
Life Science
Biology
Material Type:
Lecture
Provider:
M.I.T.
Provider Set:
M.I.T. Blossoms
Author:
Christian Schubert
Date Added:
02/15/2018
Adaptations for Bird Flight – Inspiration for Aeronautical Engineering
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Educational Use
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This activity first asks the students to study the patterns of bird flight and understand that four main forces affect the flight abilities of a bird. They will study the shape, feather structure, and resulting differences in the pattern of flight. They will then look at several articles that feature newly designed planes and the birds that they are modeled after. The final component of this activity is to watch the Nature documentary, "Raptor Force" which chronicles the flight patterns of birds, how researchers study these animals, and what interests our military and aeronautical engineers about these natural adaptations. This activity serves as an extension to the biomimetics lesson. Although students will not be using this information in the design process for their desert resort, it provides interesting information pertaining to the current use of biomimetics in the field of aviation. Students may extend their design process by using this information to create a means of transportation to and from the resort if they chose to.

Subject:
Engineering
Life Science
Biology
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Date Added:
09/18/2014
Advanced Animal Behavior, Spring 2000
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Reviews selected issues including learning, cognition, perception, foraging and feeding, migration and navigation, defense, and social activities including conflict, collaboration, courtship and reproduction, and communication. The interacting contributions of environment and heredity are examined and the approaches of psychology, ethology, and ecology to this area of study are treated. The relation of human behavior patterns to those of nonhuman animals is explored. Additional readings and a paper are required for graduate credit.

Subject:
Biology
Psychology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Schneider, Gerald
Date Added:
01/01/2000
Affect: Biological, Psychological, and Social Aspects of Feelings, Spring 2013
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This course studies the relations of affect to cognition and behavior, feeling to thinking and acting, and values to beliefs and practices. These connections will be considered at the psychological level of organization and in terms of their neurobiological and sociocultural counterparts.

Subject:
Biology
Psychology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Chorover, Stephan
Date Added:
01/01/2009
Analysis of Biological Networks (BE.440), Fall 2004
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This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work will culminate in the preparation of a unique grant application in an area of biological networks.

Subject:
Biology
Chemistry
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Essigmann, John
Sasisekharan, Ram
Date Added:
01/01/2004
Animal Behavior, Fall 2013
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Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.

Subject:
Biology
Ecology
Psychology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Schneider, Gerald
Date Added:
01/01/2013
Antibiotics, Toxins, and Protein Engineering, Spring 2007
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The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Subject:
Biology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Sassanfar, Mandana
Date Added:
01/01/2007
Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer, Fall 2006
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In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Subject:
Biology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Randell, John
Date Added:
01/01/2006
Bacteria Are Everywhere!
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Educational Use
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Students are introduced to the concept of engineering biological organisms and studying their growth to be able to identify periods of fast and slow growth. They learn that bacteria are found everywhere, including on the surfaces of our hands. Student groups study three different conditions under which bacteria are found and compare the growth of the individual bacteria from each source. In addition to monitoring the quantity of bacteria from differ conditions, they record the growth of bacteria over time, which is an excellent tool to study binary fission and the reproduction of unicellular organisms.

Subject:
Engineering
Life Science
Biology
Chemistry
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Janet Yowell
Jasmin Hume
Date Added:
09/18/2014
Bacteria Culture Club
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Yogurt is the byproduct of hungry bacteria that digest the lactose in milk. You can make more yogurt just by feeding the bacteria more milk.

Subject:
Biology
Material Type:
Activity/Lab
Provider:
Exploratorium
Provider Set:
Science Snacks
Date Added:
09/04/2019
Bean-Counter Evolution
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Hunt for prey and discover the meaning of evolutionary “fitness” in this physically active group game. In this simulation game, teams of predators equipped with genetically different “mouths” (utensils) hunt for “prey” (assorted beans). Over several “generations” of play, the fittest among the predators and prey dominate the population, modeling the evolutionary process of natural selection.

Subject:
Biology
Material Type:
Activity/Lab
Provider:
Exploratorium
Provider Set:
Science Snacks
Date Added:
09/04/2019
Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy, Fall 2009
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" Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching."

Subject:
Biology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Flygare, Johan
Wong, Bill
Date Added:
01/01/2009
Biochemical Engineering, Spring 2005
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This course focuses on the interaction of chemical engineering, biochemistry, and microbiology. Mathematical representations of microbial systems are featured among lecture topics. Kinetics of growth, death, and metabolism are also covered. Continuous fermentation, agitation, mass transfer, and scale-up in fermentation systems, and enzyme technology round out the subject material.

Subject:
Biology
Chemistry
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Prather, Kristala
Date Added:
01/01/2005
Biological Computing: At the Crossroads of Engineering and Science, Spring 2005
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Imagine you are a salesman needing to visit 100 cities connected by a set of roads. Can you do it while stopping in each city only once? Even a supercomputer working at 1 trillion operations per second would take longer than the age of the universe to find a solution when considering each possibility in turn. In 1994, Leonard Adleman published a paper in which he described a solution, using the tools of molecular biology, for a smaller 7-city example of this problem. His paper generated enormous scientific and public interest, and kick-started the field of Biological Computing, the main subject of this discussion based seminar course. Students will analyze the Adleman paper, and the papers that preceded and followed it, with an eye for identifying the engineering and scientific aspects of each paper, emphasizing the interplay of these two approaches in the field of Biological Computing. This course is appropriate for both biology and non-biology majors. Care will be taken to fill in any knowledge gaps for both scientists and engineers.

Subject:
Biology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Khodor, Julia
Date Added:
01/01/2005
Biological Engineering Design, Spring 2010
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This course illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. It uses a case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles; the responsibility scientists, engineers, and business executives have for the consequences of their technology; and instruction and practice in written and oral communication. The topic focus of this class will vary from year to year. This version looks at inflammation underlying many diseases, specifically its role in cancer, diabetes, and cardiovascular disease.

Subject:
Biology
Chemistry
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Banuazizi, Atissa
Breindel, Harlan
Essigmann, John
Irvine, Darrell
Poe, Mya
White, Forest
Date Added:
01/01/2010
Biological Engineering II: Instrumentation and Measurement, Fall 2006
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This course covers sensing and measurement for quantitative molecular/cell/tissue analysis, in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies; electro-mechanical probes such as atomic force microscopy, laser and magnetic traps, and MEMS devices; and the application of statistics, probability and noise analysis to experimental data.

Subject:
Electronic Technology
Biology
Statistics and Probability
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
So, Peter
Date Added:
01/01/2006
Biological Engineering Programming, Spring 2006
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In this course problems from biological engineering are used to develop structured computer programming skills and explore the theory and practice of complex systems design and construction.

Subject:
Biology
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Endy, Andrew
Date Added:
01/01/2006
Biology 101A Lab Packet
Unrestricted Use
CC BY
Rating

Lab Manual for BIO101 at Mt Hood Community College. The associated textbook is available at https://openoregon.pressbooks.pub/mhccbiology101/

Subject:
Biology
Material Type:
Activity/Lab
Provider:
OpenOregon
Author:
Christine Anderson
Lisa Bartee
Date Added:
02/16/2018
Biology I
Unrestricted Use
CC BY
Rating

An introduction to biology intended for non-science majors.  Focus areas include chemical foundations, cell structure and division, genetics, and evolution.

Subject:
Biology
Material Type:
Full Course
Textbook
Provider:
Lumen Learning
Provider Set:
Candela Courseware
Author:
David Fernandez
Leslie Orzetti
Paula Rodgers
Date Added:
02/16/2018