This is a seminar based on research literature. Papers covered are selected to illustrate important problems and approaches in the field of computational and systems biology, and provide students a framework from which to evaluate new developments. The MIT Initiative in Computational and Systems Biology (CSBi) is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D. program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology.

Students carry out independent experimental study under the direction of a member of the Biology Department faculty. Subject allows students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. Written and oral presentation of the research results is required. The permission of the faculty supervisor and the Biology Undergraduate Office must be obtained in advance. Instruction and practice in written and oral communication provided.

Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

it would be ideal if students already have learned that DNA is the genetic material, and that DNA is made up of As, Ts, Gs, and Cs. It also would help if students already know that each human has two versions of every piece of DNA in their genome, one from mom and one from dad. The lesson will take about one class period, with roughly 30 minutes of footage and 30 minutes of activities.

it would be ideal if students already have learned that DNA is the genetic material, and that DNA is made up of As, Ts, Gs, and Cs. It also would help if students already know that each human has two versions of every piece of DNA in their genome, one from mom and one from dad. The lesson will take about one class period, with roughly 30 minutes of footage and 30 minutes of activities.

How do scientists discover the basic biology underlying human diseases? Simple organisms such as baker's yeast, nematodes, fruit flies, zebrafish, mice and rats have allowed biologists to investigate disease at multiple levels, from molecules to behavior. In this course students will learn strategies of disease modeling by critically reading and discussing primary research articles. We will explore current models of neurodegenerative diseases such as Parkinson's disease, childhood genetic diseases such as Fragile X syndrome, as well as models of deafness and wound healing. Our goal will be to understand the strategies biologists use to build appropriate models of human disease and to appreciate both the power and limitations of using simple organisms to analyze human disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the growth and spread of cancer cells to secondary sites. We will discuss the caveats and potential pitfalls of targeting tumor blood vessels to starve cancer cells and prevent the spread of cancer, which remains one of the leading causes of death in the USA. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Objective
SWBAT prepare and observe cells from both a plant (onion) and animal (cheek).

Big Idea
Cells can vary in size, shape, and function, but they all have some features in common. In this two day investigation, students will use a microscope to explore and discover!

Views of the National Parks can be used in the classroom in many different ways. Most simply, it can be made available for students to explore on their own. Lesson plan available: Biodiversity Right Outside – Biodiversity is the abundance and variety of life-forms (animals, plants, fungi, and microorganisms) at all levels of organization (ecosystems, species, and genes). In this activity students will learn about biodiversity, the importance of biodiversity to ecosystems, and will conduct their own biodiversity study.

Like a real microscope, the Virtual Microscope allows students to examine slide samples more closely. They are able to collect samples and save them for further observation. This is used in Lesson 12 of Unit 7.3 of the OpenSciEd curriculum.

Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct experiments to answer the questions and critically interpret data. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Students are presented with information that will allow them to recognize that yeasts are unicellular organisms that are useful to humans. In fact, their usefulness is derived from the contrast between the way yeast cells and human cells respire. Specifically, while animal cells derive energy from the combination of oxygen and glucose and produce water and carbon dioxide as by-products, yeasts respire without oxygen. Instead, yeasts break glucose down and produce alcohol and carbon dioxide as their by-products. The lesson is also intended to provoke questions from students about the effects of alcohol on the human body, to which the teacher can provide objective answers.

Objective
SWBAT analyze articles to determine the complexities and required skills of recovering fossils.

Big Idea
What we can learn from fossils? Dig 'em up, put 'em together, figure it out.

Objective
SWBAT describe the importance of decomposers in composting.

Big Idea
In this lesson, students will sort biodegradable and non-biodegradable materials. Then, teams of students will research the question, "What is composting?" and will make an idea web on a team poster.

The major purpose of this lesson is to promote the learning of eye function by associating eye problems and diseases to parts of the eye that are affected. Included in this module are discussions and activities that teach about eye components and their functions. The main activity is dissecting a cow eye, which in many high schools is part of the anatomy curriculum. This lesson extends the curriculum by discussing eye diseases that students might be familiar with. An added fun part of the lesson is discussion of what various animals see.

The major purpose of this lesson is to promote the learning of eye function by associating eye problems and diseases to parts of the eye that are affected. Included in this module are discussions and activities that teach about eye components and their functions. The main activity is dissecting a cow eye, which in many high schools is part of the anatomy curriculum. This lesson extends the curriculum by discussing eye diseases that students might be familiar with. An added fun part of the lesson is discussion of what various animals see.

" During this course, we will study the similarities between cancer and normal development to understand how tumors co-opt normal developmental processes to facilitate cancer initiation, maintenance and progression. We will examine critical signaling pathways that govern these processes and, importantly, how some of these pathways hold promise as therapeutic targets for cancer treatment. We will discuss how future treatments might be personalized to target cancer cells in specific patients. We will also consider examples of newly-approved drugs that have dramatically helped patients combat this devastating disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching."

Objective
SWBAT explain the role of decomposers in an ecosystem.

Big Idea
In this lesson, students will be continue learning about decomposers, including mold and yeast, which are both types of fungi. Then, students will complete an investigation using bananas and yeast!

Objective
SWBAT to compare and contrast the central and peripheral nervous system.

Big Idea
Introduction to nervous system specifically its two subsystems, central and peripheral nervous system.